Postdoctoral Researcher - Next-Generation CAR Immune Cell Therapies Against Malignant Brain Tumors (ERC-funded), 100 %
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Description du poste
### The University of Zurich, Switzerland's largest university, offers a range of attractive positions in various subject areas and professional fields. With around 10,000 employees and currently 12 professional apprenticeship streams the University offers an inspiring working environment on cutting-edge research and top-class education. Put your talent and skills to work with us. Find out more about UZH as an employer! ### Your responsibilities **Specific project goals:** * Generate CAR immune cell communities, comprising mixtures of engineered T cells, NK cells, monocytes, and additional cell types, using sophisticated in vitro and in vivo engineering platforms. * Identify co-factors that boost CAR immune cell function using cutting-edge screening platforms. * Investigate anti-tumor activity and immune-cancer-cell environmental crosstalk in vitro and in vivo using sophisticated disease models (organoids, slice cultures, patient-derived samples, mouse models) and modern technologies including flow cytometry, multiplexed imaging, spatial transcriptomics/proteomics and single-cell profiling. * Analyze patient samples from an accompanying clinical trial evaluating CAR immune cell communities. Your profile * Intellectual curiosity, creativity and a proactive approach to problem-solving * Motivation to contribute to a project with direct patient impact * PhD in immunology, computational immunology, cell/molecular/cancer biology, bioengineering, biomedical sciences, or a related field * Experience with immune cell engineering, cellular immunotherapy, and/or advanced in vitro/in vivo disease models is highly desirable * Familiarity with single-cell and/or spatial technologies is a plus * Strong publication record demonstrating scientific productivity * Excellent communication skills and the ability to thrive in an interdisciplinary team Tobias Weiss Prof. Dr. med. Dr. sc. nat. tobias.weiss@usz.ch
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